BioXcel has been exploring the effectiveness of BXCL701, and its highly inflammatory mechanism of action, to treat … BXCL701 is designed to activate innate immune cells, specifically macrophages, by inhibiting the dipeptidyl dipeptidases DPP8 and DPP9, a novel mechanism, and … About BXCL701 BXCL701 is an investigational orally-available systemic innate-immune activator with dual mechanisms of action. We believe our candidate, BXCL501, with its unique mechanism and convenient oral dosing, has the potential to rapidly reduce agitation associated … BXCL701 differentiates itself by … BioXcel Therapeutics, Inc. (BTI) (BTAI), today announced an update of its immuno-oncology program for BXCL701, an orally-available systemic innate-immune activator with dual mechanisms of action. BXCL701 differentiates itself by activating the innate immune system and stimulating neutrophils, natural killer cells and effector T cells. However, it is ironic to note that after a further 20 years of intensive investigation, it is clear that the mechanism of action of Bcl-2 is quite distinct from Ced-9, which sequesters the activator of the caspase protease that is the ultimate effector of apoptosis. DPP8/9 Inhibition - The Primary Mechanism of BioXcel Therapeutics’ Lead Immuno-Oncology Asset, BXCL701, Highlighted in Peer... - BTAI 26/05/2020 15:52:07 1-888-992-3836 Free Membership Login "This publication highlights one component of BXCL701’s dual mechanism of action, providing valuable insights on the effects of DPP8/9 inhibition. It has shown single agent activity in melanoma and safety has been evaluated in more than 700 healthy subjects and cancer patients. At the same time, BXCL701 triggers a highly inflammatory form of a programmed cell death, known as pyroptosis, against certain types of cells.

Nature Medicine article expands upon mechanistic findings and presents DPP8/9 inhibition as potential treatment for various cancer types BXCL701 being developed for two rare malignancies:... | July 24, 2018

BXCL701 is designed to activate innate immune cells, specifically macrophages, by inhibiting the dipeptidyl dipeptidases DPP8 and DPP9, a novel mechanism, and exerts immune stimulatory activity through a pro-inflammatory form of programmed cell death known as pyroptosis.

This study is designed to assess the biochemical and immunomodulatory effects of BXCL701 in pancreatic cancer. BTI is a clinical-stage biopharmaceutical development company utilizing novel artificial intelligence approaches Expansion of clinical development for BXCL701 program planned in hematological malignancies, beyond solid tumors Confirmation and further extension of key findings in Nature Medicine... | September 4, 2019 At the same time, BXCL701 triggers a highly inflammatory form of a programmed cell death, known as pyroptosis, against certain types of cells. Turning the conversation over to our immuno-oncology clinical candidates, BXCL701, our orderly over available systemic innate immunity activator designed with a dual mechanism of action. DPP8/9 Inhibition - The Primary Mechanism of BioXcel Therapeutics’ Lead Immuno-Oncology Asset, BXCL701, Highlighted in Peer-Reviewed Journal, Stocks: BTAI, release date:Jul 24, 2018 “This publication highlights one component of BXCL701’s dual mechanism of action, providing valuable insights on the effects of DPP8/9 inhibition. BXCL701 differentiates itself by activating the innate immune system and stimulating neutrophils, natural killer cells and effector T cells. Expansion of clinical development for BXCL701 program planned in hematological malignancies, beyond solid tumors (Pancreatic BXCL701's primary mechanism of action has recently been highlighted in multiple peer reviewed journals, providing an important validation of the scientific rationale behind BXCL701…

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