The following step should be the assessment of fetal Rh D status to determining if the pregnancy is at risk for the development of hemolytic disease of the fetus and newborn. If the pregnancy is stillborn (and no sample can be obtained from the baby), anti-D should be given. so my ICT was negative but my gynaec gave me an injection of Anti D between 28-30 week and now my ICT is positive with 1:64 titre value. But you were not given any injection as u mentioned. Women who are Rh D negative with a positive anti D antibody screen test are considered Rh alloimmunized (1,2). You may be offered a dose of anti-D if you have a sensitising event, such as a bump or an accident. Hermann M, Kjellman H. During 1968-1973 510 Rh-negative, non-Rh-immunized primi- and multigravidae giving birth to Rh-positive infants, regardless of the ABO constellation, received 250 mug immunoglobulin anti-D post partum. This anti-D immunoglobulin helps to remove the RhD foetal blood cells before they can cause sensitisation. Anti-D administration of a rhesus-negative mother following a sensitising event, predominantly the birth of a rhesus-positive infant but also following a known PSE in pregnancy ; Routine antenatal anti-D prophylaxis (RAADP) most commonly given as a one-dose injection of anti-D (1500 i.u.
Otherwise, you'll be offered anti-D injections at routine times in your pregnancy.

Q - How long does prophylactic anti-D treatment continue to be effective?A - A Rhesus-negative woman may develop antibodies during her first pregnancy when her fetus is Rh-positive. Thanks to prophylaxis with anti-D immunoglobulin, sensitisation during pregnancy and after childbirth can now largely be prevented. IM) at 28–30 weeks of pregnancy. Shabnam, same is my case 33 week and i am A - amd my hubby is A +. against D-positive blood cells and so to prevent the development of HDFN in an unborn baby. my doc said she wanted to know titre value for future.
If a woman has developed anti-D antibodies in a previous pregnancy (she's already sensitised) then these immunoglobulin injections don't help. She said becauase of injection its now positive. After a Kleihauer test, at least 500 IU of anti-D should be given to every non-sensitised RhD-negative woman, within 72 hours of delivering a rhesus-positive infant. Antibodies develop most frequently after the 28th week of gestation. Rh D negative woman with no preformed anti-D to ensure adequate protection against immunisation for the following indications up to and including 12 weeks gestation (level IV evidence): — miscarriage; — termination of pregnancy; — ectopic pregnancy; and — chorionic villus sampling.

Anti-D neutralises any blood cells from your RhD-positive baby before your body has a chance to make antibodies.


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